FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS
Identifieur interne : 001727 ( Main/Exploration ); précédent : 001726; suivant : 001728FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS
Auteurs : H. J. A. Fleury [États-Unis] ; Rachel D. Sheppard [États-Unis] ; M. B. Bornstein [États-Unis] ; C. S. Raine [États-Unis]Source :
- Neuropathology and Applied Neurobiology [ 0305-1846 ] ; 1980-05.
English descriptors
- Teeft :
- Albert einstein college, Animals inoculated, Autoimmune demyelination, Axon, Brain homogenates, Cell processes, Clinical signs, Control animals, Cord, Demyelination, Dorsal root, Electron microscopy, Encephalomyelitis, Endothelial cells, Ependymal, Ependymal cells, Extensive destruction, Extracellular space, Fleury, Giant cell, Giant cell formation, Giant cells, Haematogenous origin, Higher magnification, Impending phagocytosis, Infectious virus, Inoculated, Inoculated intracerebrally, Inoculation, Japanese journal, Kersting pette, Laboratory inuestigation, Lampert, Lesion, Light microscopy, Liver tissue, Macrophage, Mature virions, Mouse, Mouse hepatitis virus, Mouse inoculated, Multinucleated giant cell, Murine virus, Myelin, Myelin degradation, Myelin pathology, Myelinated axons, Myelinated regions, Naked axons, Nerve fibres, Neuron, Oligodendrocyte, Periventricular zones, Powell lampert, Raine, Spinal, Spinal cord, Spinal cord lesions, Stohlman weiner, Suckling mouse brain, Thin sections, Ventricular margin, Ventricular space, Viral assays, Virion, Virus, Virus encephalomyelitis, Virus infection, Virus particles, Virus suspension, Virus titres, Weiner, White matter.
Abstract
Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 Neuropathology and Applied Neurobiology 6,165–179 Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.
Url:
DOI: 10.1111/j.1365-2990.1980.tb00288.x
Affiliations:
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J. A." last="Fleury">H. J. A. Fleury</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461</wicri:regionArea><wicri:noRegion>New York 10461</wicri:noRegion></affiliation></author><author><name sortKey="Sheppard, Rachel D" sort="Sheppard, Rachel D" uniqKey="Sheppard R" first="Rachel D." last="Sheppard">Rachel D. Sheppard</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461</wicri:regionArea><wicri:noRegion>New York 10461</wicri:noRegion></affiliation></author><author><name sortKey="Bornstein, M B" sort="Bornstein, M B" uniqKey="Bornstein M" first="M. B." last="Bornstein">M. B. Bornstein</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461</wicri:regionArea><wicri:noRegion>New York 10461</wicri:noRegion></affiliation></author><author><name sortKey="Raine, C S" sort="Raine, C S" uniqKey="Raine C" first="C. S." last="Raine">C. S. Raine</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology (Neuropathology), Neurology and Neuroscience and The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461</wicri:regionArea><wicri:noRegion>New York 10461</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Correspondence address: Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461</wicri:regionArea><wicri:noRegion>New York 10461</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Neuropathology and Applied Neurobiology</title><title level="j" type="alt">NEUROPATHOLOGY APPLIED NEUROBIOLOGY</title><idno type="ISSN">0305-1846</idno><idno type="eISSN">1365-2990</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="165">165</biblScope><biblScope unit="page" to="179">179</biblScope><biblScope unit="page-count">15</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1980-05">1980-05</date></imprint><idno type="ISSN">0305-1846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albert einstein college</term><term>Animals inoculated</term><term>Autoimmune demyelination</term><term>Axon</term><term>Brain homogenates</term><term>Cell processes</term><term>Clinical signs</term><term>Control animals</term><term>Cord</term><term>Demyelination</term><term>Dorsal root</term><term>Electron microscopy</term><term>Encephalomyelitis</term><term>Endothelial cells</term><term>Ependymal</term><term>Ependymal cells</term><term>Extensive destruction</term><term>Extracellular space</term><term>Fleury</term><term>Giant cell</term><term>Giant cell formation</term><term>Giant cells</term><term>Haematogenous origin</term><term>Higher magnification</term><term>Impending phagocytosis</term><term>Infectious virus</term><term>Inoculated</term><term>Inoculated intracerebrally</term><term>Inoculation</term><term>Japanese journal</term><term>Kersting pette</term><term>Laboratory inuestigation</term><term>Lampert</term><term>Lesion</term><term>Light microscopy</term><term>Liver tissue</term><term>Macrophage</term><term>Mature virions</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Mouse inoculated</term><term>Multinucleated giant cell</term><term>Murine virus</term><term>Myelin</term><term>Myelin degradation</term><term>Myelin pathology</term><term>Myelinated axons</term><term>Myelinated regions</term><term>Naked axons</term><term>Nerve fibres</term><term>Neuron</term><term>Oligodendrocyte</term><term>Periventricular zones</term><term>Powell lampert</term><term>Raine</term><term>Spinal</term><term>Spinal cord</term><term>Spinal cord lesions</term><term>Stohlman weiner</term><term>Suckling mouse brain</term><term>Thin sections</term><term>Ventricular margin</term><term>Ventricular space</term><term>Viral assays</term><term>Virion</term><term>Virus</term><term>Virus encephalomyelitis</term><term>Virus infection</term><term>Virus particles</term><term>Virus suspension</term><term>Virus titres</term><term>Weiner</term><term>White matter</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fleury H.J.A., Sheppard R.D., Bornstein M.B. & Raine C.S. 1980 Neuropathology and Applied Neurobiology 6,165–179 Further ultrastructural observations of virus morphogenesis and myelin pathology in JHM virus encephalomyelitis Groups of 3, 17, and 28‐day‐old Swiss mice were inoculated intracerebrally with JHM virus, the neurotropic strain of mouse hepatitis virus (MHV), and studied serially by virologic and morphologic techniques. Beginning 2–5 days post‐inoculation, all groups of infected mice developed CNS lesions which were destructive in the 3‐day‐old group and demyelinative in the 17 and 28‐day‐old animals. Infectious virus could be isolated from the brain, spinal cord, and liver. Electron microscopy demonstrated the virus to be pantropic in the CNS with virions occurring within ependymal cells, astrocytes, neurons, oligodendrocytes, endothelial cells, and cell of haematogenous origin. Giant cell formation was a constant feature. In regions of demyelination, oligodendrocytes exhibited a propensity to proliferative aberrant membrane. Myelin degradation was accompanied by membrane vesiculation and by the stripping action of macrophages. The lesions were not due to CNS elements in the inoculum since in animals inoculated with normal CNS suspensions from appropriate age groups failed to show lesions. The morphogenesis of JHM virions was followed ultrastructurally as was the formation of syncytia in the different cell types. In addition to delineating virus morphogenesis and myelin pathology, the results underscore the pantropic nature of JHM virus in the CNS, the systemic nature of the infection, and that oligodendrocytes were the principal targets.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Fleury, H J A" sort="Fleury, H J A" uniqKey="Fleury H" first="H. J. A." last="Fleury">H. J. A. Fleury</name></noRegion><name sortKey="Bornstein, M B" sort="Bornstein, M B" uniqKey="Bornstein M" first="M. B." last="Bornstein">M. B. Bornstein</name><name sortKey="Raine, C S" sort="Raine, C S" uniqKey="Raine C" first="C. S." last="Raine">C. S. Raine</name><name sortKey="Raine, C S" sort="Raine, C S" uniqKey="Raine C" first="C. S." last="Raine">C. S. Raine</name><name sortKey="Sheppard, Rachel D" sort="Sheppard, Rachel D" uniqKey="Sheppard R" first="Rachel D." last="Sheppard">Rachel D. Sheppard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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